Impaired insulin clearance as a cause rather than a consequence of insulin resistance
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چکیده
منابع مشابه
Impaired insulin clearance as a cause rather than a consequence of insulin resistance
Impaired insulin sensitivity and reduced b-cell function have been regarded as the two major physiological defects in type 2 diabetes mellitus. It is generally accepted that the initial defect in this disease is insulin resistance, which is typically elicited by overeating and decreased physical activity, both of which are tightly linked with obesity. b-Cells then compensate for insulin resista...
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Insulin has an exercise-like action to increase microvascular perfusion of skeletal muscle and thereby enhance delivery of hormone and nutrient to the myocytes. With insulin resistance, insulin's action to increase microvascular perfusion is markedly impaired. This review examines the present status of these observations and techniques available to measure such changes as well as the possible u...
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ژورنال
عنوان ژورنال: Journal of Diabetes Investigation
سال: 2017
ISSN: 2040-1116
DOI: 10.1111/jdi.12717